To use LiSA simply assign relationships with your contacts such as brother, boss, lover and so on.LiSA understands replies so can also say: "You have a reply from your boss". LiSA can announce all incoming messages or only those where you have assigned relationships - it's your choice.
LiSA the Liquid Information Speaking Assistant, speaks with a real human voice when emails arrive, telling you who they are from:
LiSA for MacOS X Lion
LiSA for iPhone
LiSA includes a set of 50 voicetones for your iPhone, which will be automatically installed into iTunes on installing LiSA. To use, go into your contacts on your iPhone and choose the relevant LiSA voicetones as the ringtones for the person.